Does this comic take place in the first Diablo game?

Diablo III. It's after Malthael's death. He is the main character of this fan comic.
Here is the cover: https://www.furaffinity.net/view/29843314/

Ah, okay! Thanks for clarifying.

And I tell you what, I've been playing the hell out of Diablo 3 on XBox One, so I'll be hooked on seeing more comic pages from you.

Oh, thank you very much! I will post more pages on my FA soon.
I love Diablo series too. Diablo 2 and Diablo 3 are my fav parts. And extra "reaper of the souls" is awesome since I'm a huge fan of Malthael.
I want to inform you that comics is NSFW. ^^ I'm happy to have you as my reader if you are ok with NSFW content.

Oh, I don't mind that it's NSFW. If I can handle the sight of the Treasure Goblin Queen's teets, then I can certainly handle the sight of this comic.

Also, lately, I've been playing Diablo 3 with it's music muted, and then play classical music on Spotify while playing the game. For instance, when I fight Malthael, I play "Toccata and Fugue in D Minor". You ever do that?

Oh, right. I play Diablo 3 so much so the original saountrack is getting quite annoying. :D So yep, I always use my own music while playing. Though I've never tried classical one. Thank you for advice, will try it soon.
Once I was streaming the "riper of souls" part with funny halloween music, it was really silly but fun. :D

LOL I'll bet it was.

And here's a list of classical music tunes I recommend for you.

For each Class, most likey if you're doing a Rift run:
Barbarian - Ride of the Valkyries (fits perfectly with the female barbarian decked in the Immortal King's set)
Crusader - William Tell Overture Finale (aka Lone Ranger theme. Fits perfectly if you use Steed Charge a lot.)
Demon Hunter - Hoedown, by Aaron Copland (This was a tricky choice, but the pet companion effect from Marauder's Set seems to make this song fitting)
Monk - Sabre Dance (hey, Monks can be acrobatic, too!)
Wizard - The Sorcerer's Apprentice (try not to imagine Mickey Mouse when you play this)
Necromancer - Tales from the Crypt theme (while it is copyrighted, it sounds a lot better then "Danse Macabre", which I'll list here)

...and the Witch Doctor - Sing, Sing, Sing (the Benny Goodman version. Weird, but hey, so is the Witch Doctor. LOL)

For each Act, if you're playing the Story Mode or doing Bounties:
Act 1 - Danse Macabe, by Saint-Saens
Act 2 - Marche Slave, by Tchaikovsky
Act 3 - When Johnny Comes Marching Home, by Gould, from his American Salute suite
Act 4 - Mars: Bringer of War, by Holst
Act 5 - Dream of a Witch's Sabbath, by Berlioz, from his Symphony Fantastique suite

And then for each boss...
Skeleton King - Hall of the Mountain King
Zulton Kulle/Belial - William Tell Overture - The Storm
Seige Beast/Asmodan - O Fortuna

Diablo Himself - Night on Bald Mountain

Malthael - Toccata in Fugue in D Minor

And then as a bonus:

Tyrael - Jupitor: Bringer of Hope, by Holst (the slower segment about 2:16 in, which would make for a good church choir song)

Thank you very much for such accurate recommendations! Will try it soon for sure.