Saint Christopher is sometimes depicted with a dog's head, particularly in Eastern Orthodoxy. Belief in canine-headed people (called cynocephali) was common in medieval Europe, and there was a notable theological debate at the time regarding whether they had souls or were human (many scholars believed they did.) Cynocephali can sometimes be seen in artwork from the early church (such as in sculptures in the Vézelay Abbey, France) and intermittently appeared in some religious art until as late as the 18th century.

"What shall I say of the Cynocephali, whose dog-like head and barking proclaim them beasts rather than men? But we are not bound
to believe all we hear of these monstrosities. But whoever is anywhere born a man, that is, a rational, mortal animal, no matter
what unusual appearance he presents in color, movement, sound, nor how peculiar he is in some power, part, or quality of his nature,
no Christian can doubt that he springs from that one protoplast. We can distinguish the common human nature from that which is
peculiar and therefore wonderful."
- Augustine of Hippo, City of God, Book XVI, Chapter 8.

Read more: https://orthodoxartsjournal.org/the.....t-christopher/