Once upon a time I had the idea to combine the uber-manly Jojo's Bizarre adventure with the uber-cute Azumanga Daioh. The result, as it happens, is Azumanga Dio.
These two strips were taken straight from the Azumanga comics as a test to see if they were compatible. I think I may explore this further at some future date.
Kakyoin plays the part of Osaka here, as Dio plays the part of Chiyo. Dio makes for a cute little girl.