Splice is about two young brilliant scientists... and what they do is create hybrid organisms by splicing DNA from different species for a large pharmaceutical company... there is a sexual component to this story. There is a sexual component to the relationship between the scientists and the creature that is about as Freudian as it can get. The prime directive of any life form is to procreate, and when you create something like Dren, that's an aspect of her being that you are going to have to address, and I think what is so wonderful about the horror genre is that it gives you licence to go to places that you could never comfortably go with a normal film. Like, if we made a movie about incest, that's a film that probably not many people would want to see, but if you make a horror film, that on an almost subliminal level deals with that theme, it could actually be wildly popular. Part of the excitement of watching this film is not knowing what Dren will ultimately become. Because she evolves in her lifecycle, she evolves in a very radical way. She actually begins as something quite ugly, a creature, or a child that only a mother could love. But as she grows she turns into something quite beautiful, something that is possibly a step up on the evolutionary ladder. This film on some level, well on many levels, is about evolution, its about how Dren grows up, its about how Clive and Elsa, as characters grow up, and in some respect its about how we as a species are growing up or evolving. I'm almost certain that in what's going on with that technology, that we are going to play a hand in our own evolution