As an exercise, I tried reversing the genders of two of my more prominent characters, the Mighty Goo and Catspaw, mainly because the archetypes they represent, the gooey "Plastic Man" type and the cat-themed hero, are typically male and female respectively. Since I HATE to slavishly follow the expected, I decided to try them as the opposite of the "expected" genders.
He, um, doesn't look very masculine, tho'...OK, so I need some more practice with drawing guys.